The Proteomic Landscape of Triple Negative Breast Cancer

Here you can visualize protein expression. Select a protein by typing its name or Uniprot identifier on the write boxes of the table and the bar graph will show its expression across biological specimens. Alternatively, type a Gene Ontology term or protein family to filter for group membership.

Protein List
UniprotProteinDescriptionGene OntologyProtein FamilyCOSMIC
A0AV02-5SLC12A8S12A8_HUMAN Isoform 5 of Solute carrier family 12 member 8 OS=Homo sapiens GN=SLC12A8integral to membrane; potassium ion transport; symporter activitySLC12A transporter family
A0AV96RBM47RBM47_HUMAN RNA-binding protein 47 OS=Homo sapiens GN=RBM47 PE=1 SV=2RNA binding; nucleotide binding; nucleusRRM RBM47 family
A0AVF1TTC26TTC26_HUMAN Tetratricopeptide repeat protein 26 OS=Homo sapiens GN=TTC26 PE=2 SV=1cilium assembly; primary cilium
A0AVI2FER1L5FR1L5_HUMAN Fer-1-like protein 5 OS=Homo sapiens GN=FER1L5 PE=2 SV=2integral to membraneFerlin family
A0AVI4TMEM129TM129_HUMAN Transmembrane protein 129 OS=Homo sapiens GN=TMEM129 PE=2 SV=1integral to membraneTMEM129 family
A0AVK6E2F8E2F8_HUMAN Transcription factor E2F8 OS=Homo sapiens GN=E2F8 PE=1 SV=1cell cycle comprising mitosis without cytokinesis; cell proliferation; chorionic trophoblast cell differentiation; core promoter binding; hepatocyte differentiation; negative regulation of cytokinesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sprouting angiogenesis; transcription corepressor activity; transcription factor complex; transcription, DNA-dependent; trophoblast giant cell differentiationE2F/DP family
A0AVT1UBA6UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens GN=UBA6 PE=1 SV=1ATP binding; FAT1 activating enzyme activity; cytoplasm; ligase activity; protein ubiquitination; ubiquitin-dependent protein catabolic processUbiquitin-activating E1 family
A0FGR8-2ESYT2ESYT2_HUMAN Isoform 2 of Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2integral to membrane; plasma membraneExtended synaptotagmin family
A0JLT2MED19MED19_HUMAN Mediator of RNA polymerase II transcription subunit 19 OS=Homo sapiens GN=MED19 PE=1 SV=2RNA polymerase II transcription cofactor activity; mediator complex; nucleusMediator complex subunit 19 family
A0JNW5UHRF1BP1LUH1BL_HUMAN UHRF1-binding protein 1-like OS=Homo sapiens GN=UHRF1BP1L PE=1 SV=2
A0M8Q6IGLC7LAC7_HUMAN Ig lambda-7 chain C region OS=Homo sapiens GN=IGLC7 PE=1 SV=2antigen binding; complement activation, classical pathway; extracellular region; innate immune response; plasma membrane
A0MZ66KIAA1598SHOT1_HUMAN Shootin-1 OS=Homo sapiens GN=KIAA1598 PE=1 SV=4axon; axon guidance; cytosolShootin family
A0PJW6TMEM223TM223_HUMAN Transmembrane protein 223 OS=Homo sapiens GN=TMEM223 PE=1 SV=1integral to membrane; mitochondrionTMEM223 family
A0PJX2C20orf118CT118_HUMAN Uncharacterized protein C20orf118 OS=Homo sapiens GN=C20orf118 PE=2 SV=1OXR1 family
A0PJZ3GXYLT2GXLT2_HUMAN Glucoside xylosyltransferase 2 OS=Homo sapiens GN=GXYLT2 PE=2 SV=2O-glycan processing; UDP-xylosyltransferase activity; integral to membraneGlycosyltransferase 8 family
A0PK00TMEM120BT120B_HUMAN Transmembrane protein 120B OS=Homo sapiens GN=TMEM120B PE=2 SV=1integral to membraneTMEM12 family
A1A4S6ARHGAP10RHG10_HUMAN Rho GTPase-activating protein 10 OS=Homo sapiens GN=ARHGAP10 PE=1 SV=1Rho GTPase activator activity; apoptotic process; cytoskeleton organization; cytosol; filopodium assembly; negative regulation of apoptotic process; perinuclear region of cytoplasm; phospholipid binding; plasma membrane; regulation of apoptotic process; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
A1A5A9KIAA0999A1A5A9_HUMAN KIAA0999 protein OS=Homo sapiens GN=KIAA0999 PE=2 SV=1ATP binding; protein serine/threonine kinase activity
A1A5B4-2ANO9ANO9_HUMAN Isoform 2 of Anoctamin-9 OS=Homo sapiens GN=ANO9chloride channel activity; chloride channel complex; intracellularAnoctamin family
A1A5D9CCDC64BBICR2_HUMAN Bicaudal D-related protein 2 OS=Homo sapiens GN=CCDC64B PE=2 SV=2BICDR family

Subtype clusters were determined using hierarchical clustering of proteome profiles as reported in the manuscript that accompanies this website, Lawrence et al. (2015). Cluster membership is indicated in the protein abundance profile. Copy number and mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic Bamford et al (2004). The information in the “COSMIC” column represents proteins that are curated in the cancer gene census.